Ischemic Stroke High Impact List of Articles PPts Journals The distinction between transient ischemic attack and ischemic stroke is no more Articles from CMAJ: Canadian Medical Association Journal are provided. Postacute Delivery of GABAA α5 Antagonist Promotes Postischemic Neurological . Remote Ischemic Conditioning for Preventing and Treating Ischemic Stroke.


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Rapid in-hospital processes and a team approach are required to reduce door-to-needle times.


A median time of 20 minutes was shown to be possible in a cohort study from Helsinki, 39 but in North America median times of 60 minutes or more are typical.

Research studies are stroke ischemic journal in Berlin and Houston to examine stroke ischemic journal effects of placing CT scanners in ambulances to allow rapid imaging, remote transmission of imaging data for expert review and a thrombolysis decision, so that paramedics can deliver thrombolytic therapy in the ambulance.

Hours count Distinguishing clinically between transient ischemic attack and minor stroke is not particularly helpful for prognosis because both are associated with substantial early and day risks of major ischemic stroke, and urgent investigation and management are therefore warranted for both.

Non-ST-segment stroke ischemic journal acute coronary syndromes 46 Non-ST-segment elevation acute coronary syndromes include unstable angina and non-ST-segment elevation myocardial infarction.

Diagnosis and management of acute ischemic stroke: speed is critical

Unstable angina is considered an acute coronary syndrome in which there is no detectable release of enzymes biomarkers of myocardial necrosis. These events occur as a consequence of platelet aggregation and complex interactions among the vascular wall, leukocytes, platelets and atherogenic lipoproteins.

Non-ST-segment elevation myocardial infarction has the same pathophysiology stroke ischemic journal unstable angina but is distinguished by the release of cardiac markers of myocardial necrosis e. Management involves early risk stratification stroke ischemic journal rapid institution of medical treatments: Thrombolytic therapy is not indicated for these patients.


Early coronary angiography and revascularization are beneficial in high-risk patients with stroke ischemic journal coronary syndrome. Specialized coronary care units are prevalent worldwide, but the same is not true for stroke units.

Randomized controlled trials have shown conclusively that patients treated in dedicated stroke units fare better than those treated in general wards without the same ready access to personnel trained and experienced in managing stroke.

Conclusion Conceptually, there are broad similarities in the presentation, pathophysiology and treatment of acute ischemic stroke syndromes from the mildest transient ischemic attack or minor stroke through major ischemic stroke and acute coronary syndromes.

Two unifying concepts are that treatments must be fast and decisive and that organization of care is critical to good outcomes. Acute stroke care is rapidly stroke ischemic journal up with acute coronary care. Key points Ischemic stroke and acute coronary syndromes are similar because they stroke ischemic journal both caused by sudden arterial occlusion.

Modern Medical Management of Acute Ischemic Stroke

stroke ischemic journal Different causes and pathological processes can result in occlusion; therefore, approaches to treatment differ as well. Time to treatment is a critical factor affecting outcome for both ischemic stroke and acute coronary syndromes.

As is the case for acute coronary syndromes, coordinated systems of care are required to achieve good outcomes in patients with acute ischemic stroke. He has a US patent pending no.

International Journal of Neurorehabilitation

No other competing interests were declared. Tapuwa Musuka wrote the first draft of the manuscript and coordinated editing and revision.

Stephen Wilton, Mouhieddin Traboulsi and Stroke ischemic journal Hill edited, revised and approved the final version of the manuscript. All authors agree to act as guarantors for the work.